Vaksinasjonsstrategi for reduserte bivirkninger
3 November 2006
Current vaccination strategies are primarily based on vaccine properties associated with the development and duratin of immunity. Little research has been done to formulate a comprehensive vaccination strategy that also attempts to reduce the risk of side effects after vaccination.
As expected, the transition from water based to oil based vaccines lead to an increased incidence of side effects. From the first vaccines until those used today, optimisation work has been carried out in an attempt to reduce side effects. However, field experience revealed that vaccine-independnt factors also played a significant role in the development of side effects. New knowledge about each factor and their interaction is needed to ensure a further reduction in the risk of unacceptable side effects after vaccination.
IN 1997 Intervet Norbio initiated a research collaboration with the Institute of Marine reserach, Matre Aquaculture Reserach Station. The research project is still going on, and is schedule to end in 2003. The project aims to identify and generate new knowledge about risk factors associated with the development of side effects. Based on the new knowledge, we hope to arrive at an optimal vaccination strategy for high efficacy and reduced side effects.
The results so far are derived from work carried out on S1 smolts vaccinated with the same vaccine (which no longer is in distribution). Industrial scale trials were carried out at Matre Aquaculture Research Station, localized on teh west coast of Norway. A large number of fish were used in order to make the results as representative as possible of normal production conditions. Ongoing and new trials involving both S0 and S1 smolts will eventually complete the results already available. This brochure presents extracts from five completed trials.
The importance of the following vaccine-independent factors has been invested: Reserach partners at Matre Aquaculture Research Station were as follows: Researcher Arne Berg, Manager of Matre Aquaclture Research Station Tom Hansen and Master's student Eva-Kristine Hansen, University of Bergen.
